Center for systems biology of resistance and progression to hiv, hcv, and hiv/hcv disease
This National Institute on Drug Abuse (NIDA) P30 Center supplies the core support resources needed to apply systems biology approaches to the study of HIV/AIDS, hepatitis C virus (HCV), and HIV/HCV co-infection, chronic viral infections that are a direct consequence of drug abuse and addiction. We supply cutting-edge genomic and proteomic technologies, unique immunologic and computational approaches, and a variety of biological systems, including in vitro and ex vivo infection models and chimeric mice. In addition, we work extensively with blood and biopsy samples from diverse clinical cohorts.
The complex and heterogeneous data generated by our investigations are organized and maintained in local databases for analysis and knowledge discovery. Ongoing software development is aimed at providing the tools to integrate diverse types of data and to develop quantitative and predictive models. Our unifying theme is to integrate the use of these technologies to develop a detailed understanding of the host response to virus infection and the molecular mechanisms underlying reistance to or progression of AIDS, HIV/HCV co-infection, and HCV-associated liver disease.